What we measure
The AMR Benchmark evaluates how 30 pharmaceutical companies are responding to the global threat of AMR. In 2020, it will look at company actions relating to medicines and vaccines for bacterial and fungal infections. Find out more about the research scopes.
The AMR Benchmark evaluates 30 pharmaceutical companies, including today’s largest players in the global antibacterials market and companies with promising clinical-stage pipelines. It compares companies in three groups: large-research-based pharmaceutical companies, generic medicine manufacturers and clinical-stage biopharmaceutical companies (referred to as small and medium-sized enterprises, or SMEs).
For each Benchmark cycle, the companies are selected using specific criteria, depending on the group. For example, the Benchmark includes top antibiotic market leaders in terms of sales volume and/or value, the largest vendors of active pharmaceutical ingredients (APIs), and companies with novel clinical-stage candidates for a priority pathogens. All companies focus on antibacterial and/or antifungal medicines and vaccines. For the 2020 Benchmark, eight new companies are in scope, reflecting changes in the available data and market dynamics.
The 2018 AMR Benchmark provided a baseline analysis of company action against AMR by using a deliberately broad disease scope covering all infectious diseases. This included viral and parasitic infections such as HIV/AIDS and malaria.
The 2020 AMR Benchmark will update this baseline analysis, focusing on companies' actions to limit AMR regarding bacterial and fungal infections. The Benchmark's three research areas tailor this disease scope further, depending on the role for pharmaceutical companies – see table.
Bacteria account for a large proportion of resistant priority pathogens and have a wide geographic distribution worldwide. Resistance to antifungals and antibiotics is fueled by overuse and misuse, giving companies a key role to play in balancing access and stewardship initiatives. Manufacturing waste in the environment is another factor driving resistance to antibacterials – and an emerging area of concern for antifungals.
The 2020 Antimicrobial Resistance Benchmark will report on company actions in relation to medicines and vaccines that target bacterial and fungal infections in humans:
- Medicines: Includes all innovative and adaptive medicines, branded generics and generic medicines that are used for direct treatment of target bacterial and fungal pathogens or disease processes, regardless of formulation. Products such as medicines used only for symptomatic relief are not included.
- Vaccines: Includes both preventive and therapeutic vaccines targeting bacteria and fungi.
AMR is a global problem. Pharmaceutical companies need to take action around the world to fulfill their role in limiting AMR. The AMR Benchmark captures companies' actions globally (218 countries or territories).
A key set of Benchmark indicators measure how companies plan for or address access to antimicrobials. For these indicators, the Benchmark assesses pharmaceutical companies' actions in countries where better access is most urgently needed. For the 2020 Benchmark, there are 102 countries that meet this criteria in total, mainly low- and middle-income countries.
Defining the country scope for access indicators
The 102 countries covered by access indicators have been defined using four criteria: (1) countries’ level of income; (2) their levels of development; (3) the scope and scale of inequality in each country; and (4) their infectious disease burden.
These assessments are based on data from the World Bank, the United Nations Economic and Social Council (ECOSOC), the United Nations Development Programme (UNDP), and the Institute for Health Metrics and Evaluation (IHME), respectively.
On 15 March 2019, this page was updated following a further revision to the company scope. It was corrected to show that Amplyx is now in scope of the 2020 AMR Benchmark and F2G is not.